Results 51 to 60 of about 351,035 (243)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Generating dense subgroups of measure preserving transformations [PDF]

Proceedings of the American Mathematical Society, 1981
Except for a set of first category, all pairs of measure preserving transformations generate a dense subgroup of G, the group of all invertible measure preserving transformations of the unit interval when G has the weak topology. Consider G the group of invertible (Lebesgue) measure preserving transformations of the unit interval onto itself.
openaire   +1 more source

Predicting Rural Industrial Transformation via Coupling Coordination Between Polder-Based Spatial Features and Industrial Development

Land
Rural areas are undergoing a transformation, shifting from traditional agriculture to green and leisure industries, driven by urban–rural imbalances and environmental challenges. This transition, however, presents the growing conflicts between preserving
Wenzhu Zhou, Dawei Wang, Yiwen Zhang, Hanjing Xu   +3 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Infinite measure preserving transformations with Radon MSJ [PDF]

Israel Journal of Mathematics, 2018
Final, slightly corrected, version, to appear in Isr.
openaire   +2 more sources

Research on the Indoor Thermal Environment of Industrial Architectural Heritage Based on Human Thermal Comfort—A Case Study in Hefei (China) During Winter

Buildings
With the development of China’s social economy and urbanization, there is a significant stock of urban industrial architectural heritage. Considering the increasing demand for urban land and the renewal of idle sites, the reuse of industrial ...
Qiguo Li, Yao Zhang, Chao Wen
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Generic behavior of a measure-preserving transformation [PDF]

Ergodic Theory and Dynamical Systems, 2018
Del Junco–Lemańczyk [Generic spectral properties of measure-preserving maps and applications. Proc. Amer. Math. Soc., 115 (3) (1992)] showed that a generic measure-preserving transformation satisfies certain orthogonality conditions. More precisely, there is a dense $G_{\unicode[STIX]{x1D6FF}}$ subset of measure preserving transformations such that ...
openaire   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source