Results 41 to 50 of about 172,242 (244)
Strongly Mixing Sequences of Measure Preserving Transformations [PDF]
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Behrends, Ehrhard, Schmeling, Jörg
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Limit laws for distorted return time processes for infinite measure preserving transformations
We consider conservative ergodic measure preserving transformations on infinite measure spaces and investigate the asymptotic behaviour of distorted return time processes with respect to sets satisfying a type of Darling-Kac condition.
Bingham N. H. +7 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Generating dense subgroups of measure preserving transformations [PDF]
Except for a set of first category, all pairs of measure preserving transformations generate a dense subgroup of G, the group of all invertible measure preserving transformations of the unit interval when G has the weak topology. Consider G the group of invertible (Lebesgue) measure preserving transformations of the unit interval onto itself.
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Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Infinite measure preserving transformations with Radon MSJ [PDF]
Final, slightly corrected, version, to appear in Isr.
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Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Generic behavior of a measure-preserving transformation [PDF]
Del Junco–Lemańczyk [Generic spectral properties of measure-preserving maps and applications. Proc. Amer. Math. Soc., 115 (3) (1992)] showed that a generic measure-preserving transformation satisfies certain orthogonality conditions. More precisely, there is a dense $G_{\unicode[STIX]{x1D6FF}}$ subset of measure preserving transformations such that ...
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