Results 91 to 100 of about 7,601,117 (303)

On Equivalence of Probability Measures

The Annals of Probability, 1973
Let $H$ be a real and separable Hilbert space, $\Gamma$ the Borel $\sigma$-field of $H$ sets, and $\mu_1$ and $\mu_2$ two probability measures on $(H, \Gamma)$. Several sufficient conditions for equivalence (mutual absolute continuity) of $\mu_1$ and $\mu_2$ are obtained in this paper.
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Empowering informal caregivers and nurses to take a person-centred view: adaptation and clinical utility of the Integrated Palliative Outcome Scale (IPOS-Dem) for use in acute and community care settings

BMC Geriatrics
Background Dementia is a progressive and terminal illness. Symptoms are present for people with dementia across all stages, leading to poor quality of life and considerable carer burden.
Susanne de Wolf-Linder, Iris Kramer, Margarete Reisinger, Fliss E. M. Murtagh, Maria Schubert, Christina Ramsenthaler   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Background risk model in presence of heavy tails under dependence

Nonlinear Analysis
In this paper, we examine two problems on applied probability, which are directly connected with the dependence in presence of heavy tails. The first problem is related to max-sum equivalence of the randomly weighted sums in bivariate setup. Introducing
Dimitrios G. Konstantinides, Charalampos D. Passalidis   +1 more
doaj   +1 more source

Equivalent martingale measures and Lévy processes [PDF]

Revista Brasileira de Economia, 2006
Neste trabalho calculamos as medidas martingalas equivalentes quando os retornos dos precos dos ativos sao modelados por um Processo de Levy. Seguimos la formulacao introduzida por Gerber e Shiu (1994).
openaire   +5 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Research on the optimisation strategy of short-circuit current limitation based on quantum genetic algorithm

The Journal of Engineering, 2019
With the expansion of urban power grid, short-circuit current issue becomes more important. This study proposes an effective approach to optimise short-circuit current limiting measure configuration.
Jianlin Yang, Yuan Ji, Mingxing Guo, Weidong Qiao, Fei Fei, Mengyao Zhang   +5 more
doaj   +1 more source