Results 121 to 130 of about 15,252,222 (312)

A modular, isolated high-voltage switch for application in ion mobility spectrometry

HardwareX
Ion mobility spectrometry is an emerging technology in trace gas analysis that has moved from typical safety and security applications to many other fields ranging from environmental and food quality monitoring to medicine and life sciences. Nevertheless,
Martin Lippmann, Moritz Hitzemann, Jonas Winkelholz, David Bailey, Stefan Zimmermann   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

An open source isolated data acquisition with trigger pulse generation for ion mobility spectrometry

HardwareX
Ion mobility spectrometers (IMS) are used in a wide variety of applications, including trace gas detection in safety and security applications, but also in more analytical applications, e.g., in medicine or food quality monitoring.
Tim Kobelt, Martin Lippmann, Alexander Nitschke, Lou Kielhorn, Stefan Zimmermann   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Protein measurement with the Folin phenol reagent.

Journal of Biological Chemistry, 1951
Oliver, H., Lowry, Nira, J. Rosebrough, A. Lewis, Farr, Rose, J. Randall   +8 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A fiber array architecture for atom quantum computing

Nature Communications
Arrays of single atoms trapped in optical tweezers are increasingly recognized as a promising platform for scalable quantum computing. In both the fault-tolerant and NISQ eras, the ability to individually control qubits is essential for the efficient ...
Xiao Li, Jia-Yi Hou, Jia-Chao Wang, Guang-Wei Wang, Xiao-Dong He, Feng Zhou, Yi-Bo Wang, Min Liu, Jin Wang, Peng Xu, Ming-Sheng Zhan   +10 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

An ultra-broadband flexible conductor backed coplanar waveguide with triangular edges

Scientific Reports
This paper proposes an ultra-broadband flexible conductor backed coplanar waveguide with triangular edges (FCBCPW-TE), comprising a conductor-backed coplanar waveguide (CBCPW) and triangular arrays arranged periodically along the edges.
Tingting Xie, Pengwei Gong, Wen Xie, Jia Chai, He Jiang, Jianchun Liu   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source