Results 41 to 50 of about 30,908 (262)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Measurement Invariance of the WHODAS 2.0 in a Population-Based Sample of Youth. [PDF]

PLoS ONE, 2015
The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a brief measure of global disability originally developed for adults, which has since been implemented among samples of children and youth. However, evidence of its validity
Melissa Kimber, Jürgen Rehm, Mark A Ferro   +2 more
doaj   +1 more source

Forcing with Invariant Measures

Logica Universalis
Abstract This paper introduces a model-theoretic generalization of the notion of forcing with random reals, in which forcing gives rise to random generic structures . Specifically, we consider forcing with $$
Ackerman, Nathanael, Freer, Cameron, Golshani, Mohammad, Mirabi, Mostafa, Patel, Rehana   +4 more
openaire   +3 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Testing the Tests: Investigating Measurement Invariance in Assessments of Cognitive and Language Abilities

Современная зарубежная психология
This paper discusses the measurement invariance of assessment instruments. The purpose of measurement invariance testing is to assess the extent to which a measured construct has comparable meaning across different groups or measurement points,
T.I. Logvinenko
doaj   +1 more source

Measurement Equivalence of Subjective Well-Being Scales under the Presence of Acquiescent Response Style for the Racially and Ethnically Diverse Older Population in the United States

Survey Research Methods, 2020
Objectives. While valid assessment of subjective well-being (SWB) is at the forefront of ageing research, literature increasingly reports cross-cultural measurement invariance on scales designed to capture SWB. This study examines measurement properties
Sunghee Lee, Elizabeth Vasquez, Lindsay Ryan, Jacqui Smith   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Are you “phubbing” me? The Determinants of Phubbing Behavior and Assessment of Measurement Invariance across Sex Differences

RIMCIS, 2018
Phubbing behavior is pervasive but the examination of the determinants and measurement invariance remain deficient. The present study aims to investigate: (1) relationships between Big Five personality traits (i.e., open-mindedness, conscientiousness ...
Soo Ting T'ng, Khee Hoong Ho, Sew Kim Low   +2 more
doaj   +1 more source

Longitudinal measurement invariance of neuropsychological tests in a diverse sample from the ELSA-Brasil study

Brazilian Journal of Psychiatry, 2020
Objective: Longitudinal measurement invariance analyses are an important way to assess a test’s ability to estimate the underlying construct over time, ensuring that cognitive scores across visits represent a similar underlying construct, and that ...
Laiss Bertola, Isabela M. Benseñor, Alden L. Gross, Paulo Caramelli, Sandhi Maria Barreto, Arlinda B. Moreno, Rosane H. Griep, Maria Carmen Viana, Paulo A. Lotufo, Claudia K. Suemoto   +9 more
doaj   +1 more source