Results 101 to 110 of about 2,250,709 (315)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A model of measurement of the quality of business environment in SME segment [PDF]
, 2016 This paper presents a theoretical and methodological model of measurement of the quality of business environment in the segment of Small and Medium-Sized Enterprises (SMEs) and introduces an IQSME index.
Dobrovič, Ján +7 more
core +1 more source
Modelling the Measurement Uncertainty by Intervals
J. Univers. Comput. Sci., 1998 JUCS - Journal of Universal Computer Science Volume Nr.
Wilke,Fabiana +3 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A convolutional model of the diagnostic measurement process
, 1994 Diagnostic measurement, in both medicine and engineering services, involves performing measurements with a view to identifying the condition of, and the inputs to, the system measured. The output observed is used to infer the system input.
Ferris, T.L.J.
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Enterprise systems success: A measurement model
, 2006 Organizations make large investments in Information Systems (IS) expecting positive impacts to the organisation and its functions. Yet, there exists much controversy surrounding the 'potential' impacts of these systems, with some studies reporting ...
Sedera, Darshana
core
ON MATHEMATICAL MODELLING OF SYNTHETIC MEASURES
Mathematical Modelling and Analysis, 2018 This work deals with some properties of synthetic measures designed to differentiate objects in a multidimensional analysis. The aggregate synthetic measures are discussed here to rank the objects including those validating the concentration spread.
Boleslaw Borkowski +4 more
openaire +3 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source