Results 181 to 190 of about 3,428,833 (292)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Measurement Properties of the Japanese Oswestry Disability Index in Preoperative Patients With Lumbar Spinal Stenosis: Effect of Pain and Numbness: A Cross-Sectional Study. [PDF]

Health Sci Rep
Mizoguchi Y, Akasaka K, Suzuki K, Kimura F, Ogihara S.   +4 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Measurement Properties of PROMIS Measures Relevant to Chronic Skin Diseases.

JAMA Dermatol
Nock MR, Ershadi S, Sánchez-Feliciano A, Amstutz AV, Margolis DJ, Pusic AL, Barbieri JS.   +6 more
europepmc   +1 more source

Measurement properties of instruments to assess medical fear in children: a systematic review protocol. [PDF]

BMJ Open
Liu J, Li T, Zhu M, Lin Q, Jing G, Jinlan D.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Measurement properties of self-assessment instruments for disaster nursing competencies: a systematic literature review. [PDF]

BMC Nurs
Beckert J, Prasser A, Köhler M, Ewers M.   +3 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Health-related quality of life in patients with obstructive sleep apnea - a systematic review update assessing the quality of measurement properties of patient-reported outcome measures. [PDF]

Sleep Breath
Wildenauer A, Schöbel C, Eggert T, Braun M.   +3 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source