Results 41 to 50 of about 60,740 (266)

Moody Revisited: Least-Squares Solutions of the Union Jack Surface Plate Measurement Method

Metrology
For the calibration of surface plate, the classical Moody method is still commonly used. In this method the straightness of a number of lines over a surface plate in a union-jack configuration is measured and combined into a flatness measurement.
Han Haitjema
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Characteristics of Collimators Based on the Large-Mode-Area CMCF for Coupling Laser Beam

Applied Sciences, 2021
A new collimator based on a homemade concentric multilayer-core fiber (CMCF) is proposed and experimentally demonstrated. This collimator was fabricated using a tail fiber with large mode area and single-mode operation.
Xuran Zhang, Xiao Liang, Zhenxu Bai, Shuo Liu, Zhaoxin Geng, Tianhe Yin   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Research on Feature Variable Set Optimization Method for Data-Driven Building Cooling Load Prediction Model

Buildings
Short-term building cooling load prediction is crucial for optimizing building energy management and promoting sustainability. While data-driven models excel in this task, their performance heavily depends on the input feature set. Feature selection must
Di Bai, Shuo Ma, Liwen Wu, Kexun Wang, Zhipeng Zhou   +4 more
doaj   +1 more source

A Redundancy Mechanism Design for Hall-Based Electronic Current Transformers

Energies, 2017
Traditional current transformers (CTs) suffer from DC and AC saturation and remanent magnetization in many industrial applications. Moreover, the drawbacks of traditional CTs, such as closed iron cores, bulky volume, and heavy weight, further limit the ...
Kun-Long Chen, Ren-Shuo Wan, Yi Guo, Nanming Chen, Wei-Jen Lee   +4 more
doaj   +1 more source

Measuring the functional redundancy of biological communities: a quantitative guide [PDF]

Methods in Ecology and Evolution, 2016
Summary The preservation of ecosystem processes under ongoing biotic erosion requires that some species within affected communities perform similar functions, a property that is usually defined as functional redundancy. Although functional redundancy has recently become a relevant part of ecological research, so far there is no agreement on its ...
Bruno Enrico Leone Cerabolini, Marco Moretti, Sandrine Pavoine, Francesco de Bello, Francesco de Bello, Carlo Ricotta, Marco Caccianiga   +6 more
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source