Results 61 to 70 of about 6,971,876 (333)
Probabilistic Surfel Fusion for Dense LiDAR Mapping
, 2017 With the recent development of high-end LiDARs, more and more systems are able to continuously map the environment while moving and producing spatially redundant information.
Fookes, Clinton +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
State estimation applied to active distribution networks with minimal measurements [PDF]
, 2005 Traditionally, state estimation is applied to transmission networks to improve security and redundancy of the measurement system. This paper describes the application of state estimation to distribution networks in order to extend the observability of ...
Jenkins, Nick +2 more
core
Truly noiseless probabilistic amplification [PDF]
, 2012 Most of the schemes for "noiseless" amplification of coherent states, which have recently been attracting theoretical and experimental interest, share a common trait: The amplification is not truly noiseless, or perfect, for nonzero success probability ...
Andersson, Erika, Dunjko, Vedran
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
BuildingsShort-term building cooling load prediction is crucial for optimizing building energy management and promoting sustainability. While data-driven models excel in this task, their performance heavily depends on the input feature set. Feature selection must
Di Bai +4 more
doaj +1 more source
A Redundancy Mechanism Design for Hall-Based Electronic Current Transformers
Energies, 2017 Traditional current transformers (CTs) suffer from DC and AC saturation and remanent magnetization in many industrial applications. Moreover, the drawbacks of traditional CTs, such as closed iron cores, bulky volume, and heavy weight, further limit the ...
Kun-Long Chen +4 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Hybrid Performance of the Pierre Auger Observatory [PDF]
, 2007 A key feature of the Pierre Auger Observatory is its hybrid design, in which ultra high energy cosmic rays are detected simultaneously by fluorescence telescopes and a ground array.
Dawson, B. R.
core +1 more source