Results 181 to 190 of about 8,502,687 (299)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Validation of measurement scale for technostress in Peruvian university students. [PDF]

Front Psychol
Verde-Avalos E, Turpo-Chaparro JE, Palomino-Ccasa J, Requena-Cabral G, Malca-Peralta SS.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Evidence of validity and factorial invariance of the cultural competence measurement scale (EMCC-14) among students of healthcare sciences in Panama. [PDF]

BMC Med Educ
Agrazal-García J, Tuñón R, Pedrero V.
europepmc   +1 more source

Reliability and validity of the Healthy Fitness Measurement Scale Version 1.0 (HFMS V1.0) in Chinese people. [PDF]

BMJ Open, 2021
Qiu H, Huang C, Liu Q, Jiang L, Xue Y, Wu W, Huang Z, Xu J.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Women's experiences of and satisfaction with childbirth: Development and validation of a measurement scale for low- and middle-income countries. [PDF]

PLoS One
Bohren MA, Saad CA, Kabore C, Annerstedt KS, Hanson C, de Loenzien M, Tiendrebeogo S, Bocoum F, Ravit M, Etcheverry C, Lumbiganon P, Jampathong N, Carroli G, Gialdini C, Mac QNH, Alvesson HM, Ravalihasy A, Dumont A, Betrán AP.   +18 more
europepmc   +1 more source

ICT, Disability, and Motivation: Validation of a Measurement Scale and Consequence Model for Inclusive Digital Knowledge. [PDF]

Int J Environ Res Public Health, 2021
Medina-García M, Higueras-Rodríguez L, García-Vita MDM, Doña-Toledo L.   +3 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Assessing knowledge anxiety in researchers: a comprehensive measurement scale. [PDF]

PeerJ
Zhenlei Y, Song L, Minyi D, Qiang H.
europepmc   +1 more source