Results 41 to 50 of about 225,299 (294)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Analysis of measurement uncertainty of a surface acoustic wave micro-pressure sensor

Measurement + Control, 2019
As an important support for test and control projects, sensor’s performance is directly related to the accuracy of the measurement. To fully analyze the sources of measurement uncertainty for a surface acoustic wave micro-pressure sensor, in this study ...
Jian Huang, Yuanyuan Li, Bei Jiang, Le Cao   +3 more
doaj   +1 more source

Uncertainty assessment for a towed underwater stereo PIV system by uniform flow measurement

International Journal of Naval Architecture and Ocean Engineering, 2018
The present study aims to assess test uncertainty assessment method of nominal wake field measurement by a Stereoscopic Particle Image Velocimetry (SPIV) system in a towing tank.
Bum Woo Han, Jeonghwa Seo, Seung Jae Lee, Dong Myung Seol, Shin Hyung Rhee   +4 more
doaj   +1 more source

Uncertainty Evaluation on Temperature Detection of Middle Atmosphere by Rayleigh Lidar

Remote Sensing, 2023
Measurement uncertainty is an extremely important parameter for characterizing the quality of measurement results. In order to measure the reliability of atmospheric temperature detection, the uncertainty needs to be evaluated.
Xinqi Li, Kai Zhong, Xianzhong Zhang, Tong Wu, Yijian Zhang, Yu Wang, Shijie Li, Zhaoai Yan, Degang Xu, Jianquan Yao   +9 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Uncertainty value of %CD4+T cell measurement

Journal of Associated Medical Sciences, 2014
Laboratory results are important data that aid in diagnosis, monitoring, and prognosis. However, the variation of the results occurs once the same sample is retested due to several factors.
Saowanit Chairatanapiwong, Hataigran Siwamoke, Panthong Singbootra, Phennapha Klangsinsirikul, Sakchai Dettrairat   +4 more
doaj  

Misjudgement probability estimation of product inspection based on uncertainty

The Journal of Engineering, 2019
The product inspection process with measurement uncertainty as a quality indicator is researched. Based on the product quality control information and the design and processing precision, the relationship between the misjudgement probability and ...
Huadong Fu, Yinbao Cheng, Zhongyu Wang, Hongli Li, Xiaohuai Chen, Jing Lyu   +5 more
doaj   +1 more source

Measurement uncertainty evaluation of automatic Tan Delta and resistivity test set for transformer oil [PDF]

International Journal of Metrology and Quality Engineering, 2012
Quality of transformer oil plays vital role in the performance of transformer in electrical appliances. Measurement uncertainty is a general concept associated with any measurement and can be used in professional decision processes as well as judging ...
Mandavgade N.K., Jaju S.B., Lakhe R.R.
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source