Spatial biology in cancer epigenetics
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Evolutionary Origin of the Staphylococcal Cassette Chromosome mec (SCC mec ) [PDF]
Several lines of evidence indicate that the most primitive staphylococcal species, those of the Staphylococcus sciuri group, were involved in the first stages of evolution of the staphylococcal cassette chromosome mec
Peter Damborg +23 more
core +1 more source
EEL-1 maintains the normal PVD dendrite through MEC-3. [PDF]
(A) Representative confocal images showing the PVD dendrite pattern in mec-3(deExon2), mec-3(deExon2); eel-1(wy50785), mec-3(deExon2); PVD::mec-3(deExon2) cDNA, mec-3(wy50748), mec-3(wy50748); PVD::mec-3(deExon2), mec-3(wy50748); eel-1(wy50786).
Jianxin Xie (668046) +4 more
core +1 more source
Research on green wave transit system based on 5G-V2X
Combined with the fusion technology of MEC and C-V2X,a green wave transit system based on 5G vehicle network is studied, and relevant researches are made on the green wave transit model, application of MEC and collaborative control management.
Tian Liang, Zhang Yan, Xu Li
doaj +1 more source
MEO: An Enhanced MEC Orchestrator for Federated and Distributed MEC Systems
Resource distribution among diverse administrative domains, network operators, and geographical locations across the edge-to-cloud continuum requires suitable communication and management and orchestration (MANO) mechanisms among orchestration domains.
Palomares, Javier +4 more
openaire +2 more sources
dRG-MEC: Decentralized Reinforced Green Offloading for MEC-enabled Cloud Network
Multi-access-Mobile Edge Computing (MEC) is a promising solution for computationally demanding rigorous applications, that can meet 6G network service requirements. However, edge servers incur high computation costs during task processing. In this paper, we proposed a technique to minimize the total computation and communication overhead for optimal ...
Asad Aftab, Semeen Rehman
openaire +2 more sources
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Prescriptive Analytics for MEC Orchestration [PDF]
Orchestrating network and computing resources in Mobile Edge Computing (MEC) is an important item in the networking research agenda. In this paper, we propose a novel algorithmic approach to solve the problem of dynamically assigning base stations to MEC facilities, while taking into consideration multiple time-periods, and computing load switching and
Ceselli, Alberto +5 more
openaire +4 more sources
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source

