Results 181 to 190 of about 3,694,494 (318)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Establishment of a mouse intrauterine adhesion model via transvaginal mechanical injury guided by abdominal ultrasound. [PDF]

PLoS One
Liu X, Yuan P, Zhang X, Liu X, Li C, Zhao H, Zhang Y, Li F, Zhou P.   +8 more
europepmc   +1 more source

Identification of lubrication Regimes in Mechanical Seals using Acoustic Emission for Condition Monitoring

The quality of lubrication condition between seal faces directly affects the reliability, operating life and sealing performance of mechanical seals. Thus, the identification of lubrication regimes in face seals i.e.
Gu, Fengshou, Ball, Andrew, Towsyfyan, Hossein, Wei, Nasha   +3 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The mechano-immune-vesicle regulatory circuit: a systems framework for bone homeostasis and regeneration. [PDF]

Bioact Mater
Yang T, Dong Z, Chen L, Kou X.
europepmc   +1 more source

Mechanical dissection in an introductory engineering design module

, 2010
The introductory design module for first year students in the Department of Mechanical Engineering at the University of Strathclyde uses mechanical dissection as a focus for learning activities that seek to integrate engineering science with the prior ...
McLaren, A.J., Jenkins, Peter
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of infill parameters and thermal annealing on the mechanical behavior of FDM 3D-printed polymer. [PDF]

Sci Rep
Nassar A, Abouseriaa GE, Alshorbagy A, Megahed M, Nassar E.   +4 more
europepmc   +1 more source

Modern Mechanical Engineering

Modern Mechanical Engineering (MME) is an international journal dedicated to the latest advancement of mechanical engineering. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and ...
UBERTINI, FRANCESCO
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source