Results 211 to 220 of about 1,856,033 (268)

Changes in the Mechanical Properties of Nickel-Titanium Orthodontic Archwires After Clinical Use with Conventional and Self-Ligating Brackets. [PDF]

Dent J (Basel)
Ruiz G, Moyano J, Alcaraz I, Clusellas N, Molina N, Gil J, Artés M, Puigdollers A.   +7 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Small-Bowel Impaction Caused by Mechanical Interlocking Between Duodenal Metal and Biliary Plastic Stents. [PDF]

DEN Open
Otagiri S, Sugiura R, Wada M, Nomura A, Egami H, Wakabayashi K, Fujihata K, Katsurada T, Hirano S, Sakamoto N.   +9 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mechanical and microstructural performance evaluation for cement-based mortar: calcined mud powder. [PDF]

Sci Rep
Kurt Z.
europepmc   +1 more source

Mechanobiology of the tumor microenvironment: a review of therapeutic interactions and in vitro elasticity measurement techniques. [PDF]

J Biomed Sci
Chen TW, Yu SH, Lu SL, Yeh CH, Li PC.
europepmc   +1 more source

Mechanosensitive reactive oxygen Species:A precision medicine target for oxidative stress-related diseases. [PDF]

Mechanobiol Med
Huang K.
europepmc   +1 more source

Mechanical testing methods for orthopaedic research : an introduction. [PDF]

Bone Joint Res
Zdero R, Brzozowski P, Schemitsch EH, Yang I.   +3 more
europepmc   +1 more source

Preparation of HMX/PMMA Composite Microspheres with Excellent Properties by Photoinitiated Emulsion Polymerization. [PDF]

Molecules
Zhang S, Wu N, Jia K, Huang X, Wu X, Hou C, Li H, Wang J.   +7 more
europepmc   +1 more source