Results 251 to 260 of about 3,694,494 (318)

The biarticularity of the gastrocnemii muscles provides relevant mechanisms for managing drop-like gait perturbations in humans. [PDF]

J Exp Biol
Theodorakis C, Bohm S, Mersmann F, Arampatzis A.   +3 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Effect modification by chronic obstructive pulmonary disease, anion gap, and serum creatinine on the association between invasive mechanical ventilation and 28-day mortality in intensive care unit sepsis patients: a retrospective cohort study. [PDF]

Front Med (Lausanne)
Xue Y, Chen SX, Chen GR, Lin W, Yu XF, Lin H, Chen R.   +6 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The role of mechanical power in lung ventilation for the prevention of ventilator-induced lung injury: a narrative review. [PDF]

Eur Respir Rev
Pasledni R, Urbankowski T, Darowski M.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Tissue scaffold architecture affects implant degradation and bone tissue regeneration: A novel in silico mechanobiological model analysing cell behavior, mechanical stress and degradation kinematics. [PDF]

PLoS One
Alshammari A, Alabdah F, Li L, Cooper G.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Pinch and quadrants: a mechanical hypothesis for the site-specific incidence of breast cancer. [PDF]

Int J Clin Exp Pathol
Wang D.
europepmc   +1 more source