Results 121 to 130 of about 898,493 (283)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The mechanochemical activation study of Tsagaan-tsav zeolite
Mongolian Journal of Chemistry, 2014 Characterisation of mechanochemically activated Tsagaan-tsav zeolite has been performed. Tsagaan-tsav zeolite has been activated with a vibration mill for 2, 3, 5, 10 and 20 minutes.
Ts Zolzaya +5 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Механика машин, механизмов и материалов, 2018 The article presents the results of the experimental studies of the structural transformations of a powder mixture of ultra-high molecular weight polyethylene and 80 wt.% (45 vol.%) of the nanostructured composite B4C/W treated in a high-energy ball ...
Svetlana A. Kovaleva +2 more
doaj
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs. [PDF]
Nano Lett, 2023 Fu C +7 more
europepmc +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Исследование процесса окисления механоактивированных ультрадисперсных порошков железа [PDF]
, 2015 The oxidation of mechanically activated ultrafine iron powders was studied using X-ray powder diffractionand thermogravimetric analyzes. The powders with average particles size of 100 nm were made by the electricexplosion of wire, and were subjected to ...
Власов, Виталий Анатольевич +2 more
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source