Results 131 to 140 of about 4,244,892 (203)

Outcomes of Cardiac Resynchronization Therapy with Image-Guided Left Ventricular Lead Placement at the Site of Latest Mechanical Activation: A Systematic Review and Meta-Analysis. [PDF]

J Interv Cardiol, 2022
Allen LaPointe NM, Ali-Ahmed F, Dalgaard F, Kosinski AS, Schmidler GS, Al-Khatib SM.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Lab-Scale Evaluation of Parameters Influencing the Mechanical Activation of Kaolin Using the Design of Experiments. [PDF]

Materials (Basel)
Mañosa J, Alvarez-Coscojuela A, Maldonado-Alameda A, Chimenos JM.   +3 more
europepmc   +1 more source

Mechanical Activation of MscL Revealed by a Locally Distributed Tension Molecular Dynamics Approach. [PDF]

Biophys J, 2021
Rajeshwar T R, Anishkin A, Sukharev S, Vanegas JM.   +3 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mechanical activation and expression of HSP27 in epithelial ovarian cancer. [PDF]

Sci Rep
Buckley M, Kramer M, Johnson B, Huskin G, Berry J, Sewell-Loftin MK.   +5 more
europepmc   +1 more source

Microstructural and Optical Properties of MgAl₂O₄ Spinel: Effects of Mechanical Activation, Y₂O₃ and Graphene Additions. [PDF]

Materials (Basel), 2021
Obradovic N, Fahrenholtz WG, Corlett C, Filipovic S, Nikolic M, Marinkovic BA, Failla S, Sciti D, Di Rosa D, Sani E.   +9 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy. [PDF]

Sci Adv
Xu Y, Ying L, Lang JK, Hinz B, Zhao R.
europepmc   +1 more source

Study of the Influence of Sintering Atmosphere and Mechanical Activation on the Synthesis of Bulk Ti₂AlN MAX Phase Obtained by Spark Plasma Sintering. [PDF]

Materials (Basel), 2021
Salvo C, Chicardi E, García-Garrido C, Poyato R, Jiménez JA, Mangalaraja RV.   +5 more
europepmc   +1 more source