Results 121 to 130 of about 4,244,892 (203)

High frame rate speckle tracking echocardiography to image the left ventricular mechanical activation sequence in healthy participants and patients with left bundle branch block. [PDF]

Eur Heart J Imaging Methods Pract
Papangelopoulou K, Wouters L, Orlowska M, Caenen A, Vörös G, Ector J, D'hooge J.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mechanical Activation of cPLA2 Impedes Fatty Acid β-Oxidation in Vein Grafts. [PDF]

Adv Sci (Weinh)
Fan L, Tang Y, Liu J, Liu Y, Xu Y, Liu J, Liu H, Pang W, Guo Y, Yao W, Zhang T, Peng Q, Zhou J.   +12 more
europepmc   +1 more source

Targeting the latest site of left ventricular mechanical activation is associated with improved long-term outcomes for recipients of cardiac resynchronization therapy. [PDF]

Heart Rhythm O2, 2022
Borgquist R, Barrington WR, Bakos Z, Werther-Evaldsson A, Saba S.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

SCAR-AWARE LATE MECHANICAL ACTIVATION DETECTION NETWORK FOR OPTIMAL CARDIAC RESYNCHRONIZATION THERAPY PLANNING. [PDF]

Proc IEEE Int Symp Biomed Imaging
Xing J, Wang S, Patel AR, Bilchick KC, Epstein FH, Zhang M.   +5 more
europepmc   +1 more source

Mechanical activation of the angiotensin II type 1 receptor contributes to abdominal aortic aneurysm formation. [PDF]

JVS Vasc Sci, 2021
Hall S, Ward ND, Patel R, Amin-Javaheri A, Lanford H, Grespin RT, Couch C, Xiong Y, Mukherjee R, Jones JA, Ruddy JM.   +10 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface. [PDF]

Front Bioeng Biotechnol, 2020
Sianati S, Schroeter L, Richardson J, Tay A, Lamandé SR, Poole K.   +5 more
europepmc   +1 more source