Results 151 to 160 of about 915,324 (354)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Formation of Structure of Highly Filled UHMWPE Composites under Conditions of Intensive Mechanical Activation for Radiation Protective Materials

Механика машин, механизмов и материалов, 2019
The structural changes of the ultrahigh molecular weight polyethylene (UHMWPE) filled by 70 wt.% of the ultradisperse mechanocomposites Fe/M (M = HfC (12 об.%), TiC (26 об.%), TiB2 (27 об.%), B4C (51 об.%)) and activated by the treatment in the spherical
Viktor I. Zhornik, Svetlana A. Kovaliova, Tatyana F. Grigoryeva, Tatyana Yu. Kiseleva, Marat A. Belotserkovsky, Igor I. Taran, Igor V. Valkovich, Petr A. Vityaz, Nikolay Z. Lyakhov   +8 more
doaj  

An influence of mechanical activation on the selectivity of tetrahedrite acid leaching [PDF]

Acta Montanistica Slovaca, 2005
Sulphidic mineral - tetrahedrite Cu12Sb4S13 was subjected to leaching in a H2SO4 medium. Physico-chemical changes of a mechanically activated mineral were investigated before and after leaching using the infrared spectroscopy and the scanning electron ...
Jaroslav Briančin, Marcela Achimovičová, Peter Baláž   +2 more
doaj  

Mechanical Activation and Cation Site Disorder in MgAl₂O₄. [PDF]

Materials (Basel), 2022
Corlett CA, Frontzek MD, Obradovic N, Watts JL, Fahrenholtz WG.   +4 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Investigating the Effect of Co-Cr-Sn Ions Substitution on Microstructure and Magnetic Properties of M-type Barium Hexaferrites

Journal of Advanced Materials in Engineering, 2016
In this research, investigation of the microstructure and magnetic properties of doped barium hexaferrite with cobalt, chromium and tin with BaCoxCrxSnxFe12-3xO19 (x=0.3,0.5) formula, was performed using solid state method.
S. S. Seyyed Afghahi, M. Jafarian, M. Salehi   +2 more
doaj  

The Effect of Mechanical Activation of Fly Ash on Cement-Based Materials Hydration and Hardened State Properties. [PDF]

Materials (Basel), 2023
Akmalaiuly K, Berdikul N, Pundienė I, Pranckevičienė J.   +3 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

MULTITASK LEARNING FOR IMPROVED LATE MECHANICAL ACTIVATION DETECTION OF HEART FROM CINE DENSE MRI. [PDF]

Proc IEEE Int Symp Biomed Imaging, 2023
Xing J, Wang S, Bilchick KC, Epstein FH, Patel AR, Zhang M.   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source