Results 161 to 170 of about 438,222 (313)

MULTITASK LEARNING FOR IMPROVED LATE MECHANICAL ACTIVATION DETECTION OF HEART FROM CINE DENSE MRI. [PDF]

Proc IEEE Int Symp Biomed Imaging, 2023
Xing J, Wang S, Bilchick KC, Epstein FH, Patel AR, Zhang M.   +5 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Effect of Mechanical Activation and High Pressure High Temperature Treatment on Synthesis of Material Based on Nanostructured Boron Nitride

Механика машин, механизмов и материалов, 2019
In the paper, the study of the influence of mechanical activation (MA) and subsequent high pressure high temperature (HPHT) treatment of the powder of hexagonal boron nitride (hBN) on its structure and phase composition is given.
Vladimir T. Senyut, Svetlana A. Kovaliova, Igor V. Val’kovich , Viktor I. Zhornik, Wensheng Li, Cheng Bo, Dongqing He , Haimin Zhai   +7 more
doaj  

A modular spring-loaded actuator for mechanical activation of membrane proteins. [PDF]

Nat Commun, 2022
Mills A, Aissaoui N, Maurel D, Elezgaray J, Morvan F, Vasseur JJ, Margeat E, Quast RB, Lai Kee-Him J, Saint N, Benistant C, Nord A, Pedaci F, Bellot G.   +13 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Change of physical and chemical properties clinoptilolite after mechanical activation

, 2015
Presents experimental data depending on the specific surface area and sorption properties of the clinoptilolite powder mechanical activation times. Carried out X-ray diffraction and spec-troscopic analysis of mechanically activated zeolite.
Anastasiya G Bebiya, Pavel Y Gulyaev, Irina V Milyukova   +2 more
core   +1 more source

Mechanical Activation of Forbidden Photoreactivity in Oxa-di-π-methane Rearrangement. [PDF]

J Org Chem, 2022
Jodra A, García-Iriepa C, Frutos LM.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration. [PDF]

Front Neurol, 2023
Pastras CJ, Gholami N, Jennings S, Zhu H, Zhou W, Brown DJ, Curthoys IS, Rabbitt RD.   +7 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source