Results 181 to 190 of about 406,447 (269)

Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy. [PDF]

Sci Adv
Xu Y, Ying L, Lang JK, Hinz B, Zhao R.
europepmc   +1 more source

Study of the Influence of Sintering Atmosphere and Mechanical Activation on the Synthesis of Bulk Ti₂AlN MAX Phase Obtained by Spark Plasma Sintering. [PDF]

Materials (Basel), 2021
Salvo C, Chicardi E, García-Garrido C, Poyato R, Jiménez JA, Mangalaraja RV.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Polymer time crystal: Mechanical activation of reversible bonds by low-amplitude high frequency excitations. [PDF]

Sci Adv
Heidari M, Gaichies T, Leibler L, Labousse M.   +3 more
europepmc   +1 more source

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts. [PDF]

Cells, 2020
Godbout E, Son DO, Hume S, Boo S, Sarrazy V, Clément S, Kapus A, Wehrle-Haller B, Bruckner-Tuderman L, Has C, Hinz B.   +10 more
europepmc   +1 more source

Effect of Mechanical Activation of Al-Ti-B Powder Mixture on Phase Composition and Structure of Al-TiB₂ Composite Materials Obtained by Self-Propagating High-Temperature Synthesis (SHS). [PDF]

Materials (Basel), 2022
Matveev A, Promakhov V, Nikitin P, Babaev A, Vorozhtsov A.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MULTIMODAL LEARNING TO IMPROVE CARDIAC LATE MECHANICAL ACTIVATION DETECTION FROM CINE MR IMAGES. [PDF]

Proc IEEE Int Symp Biomed Imaging
Xing J, Wu N, Bilchick KC, Epstein FH, Zhang M.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source