Results 191 to 200 of about 438,222 (313)

Mechanical activation of PIEZO1 drives AP-1-dependent PTGS2/PGE2 signaling and corneal inflammation. [PDF]

iScience
Zou Z, Qian X, Ren J, Wang Y, Liu Y, Luo A, Guo M, Tong H, Li R, Li S, Zhang H.   +10 more
europepmc   +1 more source

Author Correction: Mechanical activation of spike fosters SARS-CoV-2 infection. [PDF]

Cell Res, 2021
Hu W, Zhang Y, Fei P, Zhang T, Yao D, Gao Y, Liu J, Chen H, Lu Q, Mudianto T, Zhang X, Xiao C, Ye Y, Sun Q, Zhang J, Xie Q, Wang PH, Wang J, Li Z, Lou J, Chen W.   +20 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

:Determination of Activation Energy of Cyanet Ester and Epoxy Resins Using Dynamic Mechanical Analysis [PDF]

The activation energy associated with the glass transition relaxation of thermosets has been determined by using the three-point bending clamp provided.
Risteska, Svetlana, Srebrenkoska, Sara, Srebrenkoska, Vineta   +2 more
core  

Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells. [PDF]

Cell Res
Wang Q, Zeng X, Yang H, Lu H, Jiang L, Xu L, Li J, Li J, Han Y, Wu X, Zhou Y, Chen X, Zhao Y, Shi J, Luo Y, Ni F, Sun J, Zhao Q, Yang F, Xia P, Jiang H, Huang H, Qian P.   +22 more
europepmc   +1 more source

Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs. [PDF]

Pharmaceutics, 2022
Martínez LM, Cruz-Angeles J, Vázquez-Dávila M, Martínez E, Cabada P, Navarrete-Bernal C, Cortez F.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The effects of age- and training-related changes in tendon stiffness on muscular force production and neuro-motor control during childhood

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The research described in this thesis examined age- and strength training-related changes in Achilles tendon stiffness and plantarflexor force production in
Waugh, Charlotte
core  

High frame rate speckle tracking echocardiography to image the left ventricular mechanical activation sequence in healthy participants and patients with left bundle branch block. [PDF]

Eur Heart J Imaging Methods Pract
Papangelopoulou K, Wouters L, Orlowska M, Caenen A, Vörös G, Ector J, D'hooge J.   +6 more
europepmc   +1 more source