Results 81 to 90 of about 1,816,806 (298)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Mechanical behavior of carbon-carbon composites [PDF]

A general background, test plan, and some results of preliminary examinations of a carbon-carbon composite material are presented with emphasis on mechanical testing and inspection techniques.
Rozak, G. A.
core   +1 more source

Variational integrators for degenerate Lagrangians, with application to point vortices [PDF]

, 2002
We develop discrete mechanics and variational integrators for a class of degenerate Lagrangian systems, and apply these integrators to a system of point vortices. Excellent numerical behavior is observed.
Marsden, Jerrold E., Rowley, Clarence W.
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Si substituted hydroxyapatite nanorods on Ti for percutaneous implants

Bioactive Materials, 2020
An ideal intraosseous transcutaneous implant should form a tight seal with soft tissue, besides a requirement of osseointegration at the bone-fixed position. Si substituted hydroxyapatite (Si-HA) nanorods releasing Si ion and simulating nanotopography of
Kai Li, Yang Xue, Ting Yan, Lan Zhang, Yong Han   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Self-supervised probabilistic models for exploring shape memory alloys

npj Computational Materials
Recent advancements in machine learning (ML) have revolutionized the field of high-performance materials design. However, developing robust ML models to decipher intricate structure-property relationships in materials remains challenging, primarily due ...
Yiding Wang, Tianqing Li, Hongxiang Zong, Xiangdong Ding, Songhua Xu, Jun Sun, Turab Lookman   +6 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Mechanical behavior of robocast alumina [PDF]

, 1998
Direct fabrication of alumina parts by robocasting was completed. This method is based on three-dimensional deposition of binderless aqueous alumina slurries. Parts were made with different deposition paths and mechanical·testing performed·to determine the effects •of bead alignment. Properties were also compared to.
Denham, H. B., Cesarano, J., III, King, B. H., Calvert, P.   +3 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source