Results 111 to 120 of about 4,706,054 (303)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

In Situ Mechanical Characterization of Intracellular and Intranuclear Structures [PDF]

Traditionally, studies provided a single value for cell properties and broad structural models. Over the past two decades, advancements in measurement techniques have transformed cell mechanics research, shifting it towards a more regional approach.
Tang, Wentian
core   +1 more source

Bending characteristics of resin concretes

Materials Research, 2003
In this research work the influence of composition and curing conditions in bending strength of polyester and epoxy concrete is analyzed. Various mixtures of resin and aggregates were considered in view of an optimal combination.
Ribeiro Maria Cristina Santos, Tavares Cassilda Maria Lopes, Figueiredo Miguel, Ferreira António Joaquim Mendes, Fernandes António Augusto   +4 more
doaj  

Effect of the Position of Defined Local Defect on the Mechanical Performance of Carbon-Fiber-Reinforced Plastics

AUTEX Research Journal, 2019
Considering their energy and resource efficiency, fiber-reinforced plastics (FRPs) have been displacing metals and metal alloys for lightweight constructions.
Ashir Moniruddoza, Nocke Andreas, Cherif Chokri   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Macro-, Micro- and Nanomechanical Characterization of Crosslinked Polymers with Very Broad Range of Mechanical Properties

, 2020
This work is focused on the comparison of macro-, micro- and nanomechanical properties of a series of eleven highly homogeneous and chemically very similar polymer networks, consisting of diglycidyl ether of bisphenol A cured with diamine terminated ...
Jiri Nohava, Adam Strachota, Beata Strachota, Veronika Gajdosova, Miroslav Slouf, Vendulka Bertschova   +5 more
core   +1 more source

Experimental and Numerical Characterization of Springback in V-Bending of AISI 304L Stainless Steel Enhanced by Machine Learning Prediction

Journal of Materials and Engineering Structures
Accurate prediction of springback is a major challenge in sheet metal forming due to the material's ductility, strain hardening, and deformation-induced martensitic transformation.
Mokhtar BENCHERIF, AbdelKrim SAIDANI, Madjid ALMANSBA, Rabah FERHOUM, Amar BOUDEDJA, Khellaf BELMIHOUB   +5 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source