Results 131 to 140 of about 317,079 (268)

Mechanical characterization of human versus porcine brain tissue under large strains. [PDF]

Biomech Model Mechanobiol
Reiter N, Nistler S, Hoffmann L, Bräuer L, Paulsen F, Budday S.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mechanical Characterization of PLA+ Specimens with Different Geometries Using Experimental and Numerical Methods. [PDF]

Polymers (Basel)
Boztepe MH, Haskul M.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels. [PDF]

Device
PereiraTavares AJ, Aranda-Michel L, Hahn S, Kaufman O, Coffin BD, Ashraf SF, Szafron JM, Straub AC, Shiwarski DJ.   +8 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Material Characterization with the Fuzzy Theory of Particleboards Bonded by Urea Formaldehyde with Nanofillers

BioResources
This study investigated the material characterization with the fuzzy theory of particleboards bonded by urea formaldehyde with nanofillers including nanofibrillated cellulose (NFC) and titanium dioxide (TiO2).
Ömer Ümit Yalçın, Uğur Özkan, Deniz Aydemir, Ahmet Öztel, Yafes Yıldız   +4 more
doaj  

Prediction of wear outcomes and mechanical characterization of innovative SiO₂ incorporated aluminium matrix composites. [PDF]

Sci Rep
Bhowmik A, Kumar R, Sharma K, Chauhan MR, Bains PS, Singh K, Gill HS, Romanovski V, Ashok N.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Mechanical characterization of PETG - carbon fiber composite parts using 3D printing for drone frame application. [PDF]

Sci Rep
Palaniappan M, Kumar PM, Arunkumar P, Gebreyohannes DT.   +3 more
europepmc   +1 more source