Results 131 to 140 of about 4,706,054 (303)

Correlation between the mechanical and histological properties of liver tissue

, 2015
In order to gain further insight into the mechanisms of tissue damage during the progression of liver diseases as well as the liver preservation for transplantation, an improved understanding of the relation between the mechanical and histological ...
Başdoğan, Çağatay; Yarpuzlu, Berkay; Ayyıldız, Mehmet; Tok, Olgu Enis; Aktaş, Ranan Gülhan
core   +1 more source

Melt Electrowritten Biodegradable Mesh Implants with Auxetic Designs for Pelvic Organ Prolapse Repair

Journal of Manufacturing and Materials Processing
Pelvic organ prolapse (POP) is a common condition among women, characterized by the descent of pelvic organs through the vaginal canal. Although traditional synthetic meshes are widely utilized, they are associated with complications such as erosion ...
Nuno Miguel Ferreira, Evangelia Antoniadi, Ana Telma Silva, António Silva, Marco Parente, António Fernandes, Elisabete Silva   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

ANALYSIS OF THE DIFFERENCE BETWEEN THE REFERENCE TEMPERATURE VALUES DERIVED FROM CONVENTIONAL AND MINI-C(T) SPECIMENS: EFFECT OF THE NUMBER OF VALID FRACTURE TESTS

Publisher Copyright: Copyright © 2025 by ASME.The Long-Term-Operation (LTO) of nuclear power plants (NPPs) requires, among other technical and scientific challenges, a precise knowledge of the fracture behavior of the steels (both base material and welds)
Cicero, Sergio, Sanchez, Marcos
core   +1 more source

Transforming Agricultural Waste into Sustainable Composite Materials: Mechanical Properties of Tamarindus Fruit Fiber (TFF)-Reinforced Polylactic Acid Composites

Engineering Proceedings
Natural fiber-based polymer composite has great potential and is in high demand due to its high specific strength, low carcinogenic nature and economic market value.
Srinivasan Rajaram, Thirugnanam Subbiah, Felix Sahayaraj Arockiasamy, Jenish Iyyadurai   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source