Results 171 to 180 of about 4,706,054 (303)

Effects of Buoyancy and Surface Roughness on Mechanical Characterization of Shipbuilding Steel by Immersion Instrumented Indentation. [PDF]

Micromachines (Basel)
Zhang X, Zhao Z, Wang Z, Li S, Sun C, Xia Y, Liu Z, Cai Y, Wang B, Wang S.   +9 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Elements of Mechanical Design

, 2010
Examination and practice in the application of many mechanical design elements, including control components. Students working in groups design, fabricate, and test prototype devices in response to requests from industrial sponsors.
Smith, Amy, Frey, Daniel
core  

Material Characterization with the Fuzzy Theory of Particleboards Bonded by Urea Formaldehyde with Nanofillers

BioResources
This study investigated the material characterization with the fuzzy theory of particleboards bonded by urea formaldehyde with nanofillers including nanofibrillated cellulose (NFC) and titanium dioxide (TiO2).
Ömer Ümit Yalçın, Uğur Özkan, Deniz Aydemir, Ahmet Öztel, Yafes Yıldız   +4 more
doaj  

Protocol for synthesis and mechanical characterization of polyacrylamide hydrogels of varying stiffness for cell culture applications. [PDF]

STAR Protoc
Cresens C, Aytekin S, Shaghaghi B, Gerrits L, Montero-Calle A, Barderas R, Kouwer P, Rocha S.   +7 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Fabrication, Simulation, and Mechanical Characterization of Curcumin-Loaded PVA/PVP Microneedle Arrays Using Custom 3D-Printed Molds. [PDF]

Polymers (Basel)
Basa BASJ, Batin CDZ, Chan INMD, Gabay ARB, Estrellado JRC, Rallos RGR, Carranza MSS, Lim MJU, Marquez JC, Sta Agueda JRH.   +9 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mechanical characterization of human umbilical and chorionic plate arteries affected by fetal growth restriction. [PDF]

PNAS Nexus
Arenas GA, Navarrete Á, Gonzalez JM, Utrera A, García-Herrera C, Krause BJ.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source