Results 191 to 200 of about 317,079 (268)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Development of Carrageenan and Starch-Based Bioplastics for Packaging Applications (Shopping Bags): Mechanical Characterization, Morphology, and Biodegradation. [PDF]

Scientifica (Cairo)
Giarni R, Sujarwadi R, Supriyatna YI, Kurniasari I, Soraya M, Putri RPG, Laksono H, Purwoto H.   +7 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Mechanical Characterization of 3D-Printed Scaffolds: A Multi-Objective Optimization Approach Using Virtual Testing and Homogenization. [PDF]

Biomimetics (Basel)
León PI, Muhlich U, Aravena PC, Martínez G.   +3 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Physico-mechanical characterization and gamma radiation shielding capability of granodiorite from Suwayqat El-Arsha, Egypt; implications for construction and natural radiation shielding. [PDF]

Sci Rep
Azer MK, Abdel-Rahman AM, Price JB, Gawad AEA, Hanfi MY.   +4 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Indenting at the Microscale: Guidelines for Robust Mechanical Characterization of Alginate Microgels. [PDF]

ACS Appl Mater Interfaces
Harder P, Funke L, Reh JT, Lieleg O, Özkale B.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Correction: Filali et al. Morphological and Mechanical Characterization of Extracellular Vesicles and Parent Human Synoviocytes under Physiological and Inflammatory Conditions. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 13201. [PDF]

Int J Mol Sci
Filali S, Darragi-Raies N, Ben-Trad L, Piednoir A, Hong SS, Pirot F, Landoulsi A, Girard-Egrot A, Granjon T, Maniti O, Miossec P, Trunfio-Sfarghiu AM.   +11 more
europepmc   +1 more source