Results 201 to 210 of about 12,483,612 (316)

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading. [PDF]

iScience
Tseng PL, Sun W, Salem A, Alaklobie M, Macfarlane SC, Gad AKB, Collins MO, Erdmann KS.   +7 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Mechanical control of cell proliferation patterns in growing epithelial monolayers. [PDF]

Biophys J
Carpenter LC, Pérez-Verdugo F, Banerjee S.   +2 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mechanical control of antigen detection and discrimination by T and B cell receptors. [PDF]

Biophys J
Rogers J, Bajur AT, Salaita K, Spillane KM.   +3 more
europepmc   +1 more source

Journal of the American Society of Mechanical Engineers.

Mode of access ...
American Society of Mechanical Engineers.
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Light-Controlled Magnetic Properties: An Energy-Efficient Opto-Mechanical Control over Magnetic Films by Liquid Crystalline Networks. [PDF]

Adv Sci (Weinh)
Barrera G, Martella D, Celegato F, Fuochi N, Coïsson M, Parmeggiani C, Wiersma DS, Tiberto P, Tiberto P.   +8 more
europepmc   +1 more source

Effect of Tempering Temperature after Thermo-Mechanical Control Process on Microstructure Characteristics and Hydrogen-Induced Ductility Loss in High-Vanadium X80 Pipeline Steel. [PDF]

Materials (Basel), 2020
Li L, Song B, Yang B, Wang L, Cheng W.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source