Results 101 to 110 of about 11,952,015 (299)

Sophie Doulut, "The Ivory Horse"

, 2023
One day I rode a magnificent ivory horse It took me up high into the sky Galloping as fast as it could, Bolting from one cloud to the other, And I finally landed Onto another soil, A foreign kingdom Where strange people Spoke a ...
The LOOP team
core  

The Optimization of Mechanical Phase-Shifting Transformer Tap Positions Based on an Open-Loop and Closed-Loop Hybrid Strategy

Energies
Phase-shifting transformers play a crucial role in power grid stability and efficiency. They adjust phase differences between loads, improve transmission efficiency, and balance loads during large-scale power transmission and grid integration.
Jinjiao Lin, Jingyan Du, Shi Chen, Xinying Wang, Haodong Long, Chuyang Wang   +5 more
doaj   +1 more source

Positioning system with backlash compensation by twin motor cooperative control (Evaluation of rectilinear motion mechanism installed planetary gear speed reducer)

Nihon Kikai Gakkai ronbunshu, 2014
Backlash occurs in gear drive systems that are used with machine tools and transport mechanisms. The problem with backlash is that it reduces positioning accuracy and tends to cause vibrations.
Toyokazu UCHIDA, Akihito ITO, Toshiya KITAMURA, Nobuyuki FURUYA   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Review on laser directed energy deposited aluminum alloys

International Journal of Extreme Manufacturing
Lightweight aluminum (Al) alloys have been widely used in frontier fields like aerospace and automotive industries, which attracts great interest in additive manufacturing (AM) to process high-value Al parts.
Tian-Shu Liu, Peng Chen, Feng Qiu, Hong-Yu Yang, Nicholas Tan Yew Jin, Youxiang Chew, Di Wang, Ruidi Li, Qi-Chuan Jiang, Chaolin Tan   +9 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

LOOP AGM 2023

, 2023
The LOOP team
core   +1 more source