Results 111 to 120 of about 11,952,015 (299)
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Control Loop Feedback Mechanism for Generic Array Logic Chip Multiprocessor
CoRR, 2014 Control Loop Feedback Mechanism for Generic Array Logic Chip Multiprocessor is presented. The approach is based on control-loop feedback mechanism to maximize the efficiency on exploiting available resources such as CPU time, operating frequency, etc.
openaire +3 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Research on control strategy of electro-mechanical braking system
机车电传动The electro-mechanical braking system utilized in rail vehicles experiences braking judder and vibration during operation. It is imperative to enhance control accuracy and develop precise control algorithms for the accurate regulation of clamping force ...
CHANG Jiujian +3 more
doaj
Applied System InnovationIn response to the demands for high reliability, excellent dynamic response, and high-precision control of advanced aircraft actuation systems, this study focuses on the control technology for the master-master operating mode of dual-redundancy electro ...
Xin Bao, Yan Li, Zhong Wang, Rui Wang
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
ELASTIC BEAM VIBRATION CONTROL WITH PHASE-LOCKED LOOP
, 2015 The Phase-Locked Loop (PLL) is a closed-loop control system that synchronizes a local oscillator to an oscillatory incoming,signal. The PLL plays important roles in communication, computation and control systems, allowing the correct flow of information ...
ASME +3 more
core +1 more source