Results 211 to 220 of about 27,037,911 (301)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluation of polyampholyte thin film hydrogels for the prevention of <i>Ralstonia pickettii</i> adhesion in microgravity. [PDF]

RSC Adv
Shea A, Oneida S, Waynant KV, Bernards MT.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

<i>Pseudomonas aeruginosa</i>: a model system for studying the behavior of unbiased flagellar motors. [PDF]

J Bacteriol
Wu Z, Tian M, Fu S, Zhang R, Yuan J.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Open-source hardware design and construction of a modular robotics kit for STEM education. [PDF]

HardwareX
Calle-Arévalo L, Gonzales JF, Naula JAO, Lituma DGZ.   +3 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Biomechanical Response Analysis of Scaffold Implantation in Mandibular Defects and Research on Scaffold Selection

ACS Omega
Lilan Gao, Zhiyi Wang, XiangLong Lin, ChunQiu Zhang, Jie Liu, Yansong Tan, Kai Sun   +6 more
doaj   +1 more source

Multifunctional Flipping-Based Mechanical Metasurface Enabling Optical-Microwave Dual-Modal Reconfigurability. [PDF]

Adv Mater
Huang S, Cai ZX, Li XY, Chen L, Xu J, Liang JY, Bao JH, Liu C, You JW.   +8 more
europepmc   +1 more source