Results 131 to 140 of about 1,509,300 (299)

Metabolic Cost and Mechanical Efficiency of a Novel Handle-Based Device for Wheelchair Propulsion. [PDF]

J Rehabil Med, 2022
Puchinger M, Kurup N, Gstaltner K, Pandy MG, Gföhler M.   +4 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Metabolic Flexibility and Mechanical Efficiency in Women Over-60. [PDF]

Front Physiol, 2022
Blasco-Lafarga C, Monferrer-Marín J, Roldán A, Monteagudo P, Chulvi-Medrano I.   +4 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Prolonged cycling lowers subsequent running mechanical efficiency in collegiate triathletes. [PDF]

BMC Sports Sci Med Rehabil, 2022
Stewart JA, Merritt EK, Lidstone DE, McBride JM, Zwetsloot KA.   +4 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Microstructure and high-temperature tribological properties of chessboard-textured (CFx)n/CaF2/C–ZrO2/TiO2 lubricant-hard alternate coatings fabricated by electrospray mask in-situ forming technology

Journal of Materials Research and Technology
The paper presents the fabrication of chessboard-structured (CFx)n/CaF2/C–ZrO2/TiO2 lubricant-hard alternate coatings by electrospray mask in-situ forming technique.
Zhihui Zhang, Jianxin Deng, Lingxuan Fan, Junyan Wang   +3 more
doaj   +1 more source

Severe loss of mechanical efficiency in COVID-19 patients. [PDF]

J Cachexia Sarcopenia Muscle, 2021
Pleguezuelos E, Del Carmen A, Llorensi G, Carcole J, Casarramona P, Moreno E, Ortega P, Serra-Prat M, Palomera E, Miravitlles MM, Yebenes JC, Boixeda R, Campins L, Villelabeitia-Jaureguizar K, Garnacho-Castaño MV.   +14 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mechanical Efficiency Investigation of an Ankle-Assisted Robot for Human Walking With a Backpack-Load. [PDF]

J Biomech Eng, 2021
Xie L, Wang Z, Huang G, Liu B, Zhou Z.
europepmc   +1 more source