Results 111 to 120 of about 1,509,300 (299)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An Investigation on Attention Mechanism–Based Long Short-Term Memory for Gearbox Fault Diagnosis

Shock and Vibration
The gearbox is widely used in various machines, and their fault diagnosis can reduce unexpected downtime and maintenance costs. Although deep learning networks (DLNs) can automatically extract features from original series data and perform diagnostic ...
Ningning Wu, Yang Li, Xiaogang Li, Keyan Yuan, Wenyuan Jiang, Ke Li   +5 more
doaj   +1 more source

Experimental Study on Grinding of Inner Raceway of Tapered Roller Bearing Outer Ring

Micromachines
Tapered roller bearings are widely employed in mechanical structures such as automotive wheel hub units, transmissions, and machine tool spindles, and they have a direct impact on the performance and stability of the equipment.
Yingqi Hou, Jiahao Xu, Ziyue Hei, Guangdi Jin, Yufei Gao   +4 more
doaj   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

An Enhanced NSGA-II Algorithm Combining Lévy Flight and Simulated Annealing and Its Application in Electric Winch Trajectory Planning: A Complex Multi-Objective Optimization Study

Machines
To overcome the limitations of traditional multi-objective evolutionary algorithms—which often become trapped in local optima when addressing complex optimization problems and face challenges in balancing convergence efficiency with population diversity ...
Enzhi Quan, Yanjun Liu, Han Gao, Huaqiang You, Gang Xue   +4 more
doaj   +1 more source

An evaluation of boron-polymer film layer composites for high-performance structures [PDF]

Fabricability, mechanical properties, and structural efficiency potentials of boron-polymer film layer ...
Crawford, R. F.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Programmable Metamaterials with Perforated Shell Group Supporting Versatile Information Processing

Advanced Science
Mechanical metamaterials have emerged as promising tools for enabling mechanical intelligence in soft machines through interaction with the external environment.
Xiaoyuan Ma, Ziran Wang, Weipeng Zhang, Peng Yan   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source