Results 101 to 110 of about 1,509,300 (299)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Numerical investigation on the prefabricated crack propagation of FV520B stainless steel

open access: yesResults in Physics, 2017
FV520B is a common stainless steel for manufacturing centrifugal compressor impeller and shaft. The internal metal flaw destroys the continuity of the material matrix, resulting in the crack propagation fracture of the component, which seriously reduces ...
Juyi Pan, Ming Qin, Songying Chen
doaj   +1 more source

A mechanical model for guided motion of mammalian cells

open access: yes, 2015
We introduce a generic, purely mechanical model for environment sensitive motion of mammalian cells that is applicable to chemotaxis, haptotaxis, and durotaxis as modes of motility.
Beck, Kristof Leon   +2 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Mechanistic Analysis of Fluid Dynamics and Multifactorial Impact Mechanisms in Inhaled Pharmaceutical Deposition for Chronic Respiratory Diseases

open access: yesBioengineering
The clinical efficacy of inhalation therapy in chronic respiratory diseases is fundamentally constrained by particle deposition patterns. This study employs computational fluid dynamics (CFD) and response surface methodology (RSM) to elucidate the ...
Fuli Hu, Songhua Ma, Tianliang Hu
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Barriers to energy efficiency: evidence from selected sectors [PDF]

open access: yes, 2003
To combat climate change, it is essential to reduce the use of fossil fuels and minimise greenhouse gas emissions. To help to achieve that objective, energy must be used efficiently.
O'Malley, Eoin   +2 more
core   +1 more source

AGN feedback in an isolated elliptical galaxy: the effect of strong radiative feedback in the kinetic mode

open access: yes, 2014
Based on two-dimensional high resolution hydrodynamic numerical simulation, we study the mechanical and radiative feedback effects from the central AGN on the cosmological evolution of an isolated elliptical galaxy.
Ciotti, Luca   +4 more
core   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Detuned Mechanical Parametric Amplification as a Quantum Non-Demolition Measurement

open access: yes, 2014
Recently it has been demonstrated that the combination of weak-continuous position detection with detuned parametric driving can lead to significant steady-state mechanical squeezing, far beyond the 3 dB limit normally associated with parametric driving.
Bowen, Warwick P.   +3 more
core   +1 more source

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