Results 41 to 50 of about 189,256 (267)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Particle Swarm Optimization-Support Vector Machine Model for Machinery Fault Diagnoses in High-Voltage Circuit Breakers

Chinese Journal of Mechanical Engineering, 2020
According to statistic data, machinery faults contribute to largest proportion of High-voltage circuit breaker failures, and traditional maintenance methods exist some disadvantages for that issue.
Xiaofeng Li, Shijing Wu, Xiaoyong Li, Hao Yuan, Deng Zhao   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Tunable Plug‐and‐Play Meta‐Nanogenerator Materials for Multi‐Range Force Measurements

Advanced Science
Accurate assessments of mechanical forces are crucial for the design, operation and maintenance of long‐lasting engineering systems. Conventional force sensors that are deployed in engineering applications suffer from multiple shortcomings including high
Roshira Premadasa, Pouya Almasi, Samriddhi Ghimire, Wenkui Dong, Chenjie Zhang, Pengcheng Jiao, Qianyun Zhang   +6 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Methods for Increasing Power Efficiency of Heating Furnaces Applied in Metallurgical and Mechanical Engineering Industries

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2011
The paper analyzes experimental data and results of balance tests of two continuous heating furnaces applied in mechanical engineering and metallurgical industries.
M. L. German, S. M. Kabishov, A. A. Oznobishin   +2 more
doaj  

An Apparatus for Measuring Heat Transfer Rate and Thermal Conductivity of Tubes جهاز لقياس معدل الانتقال الحرارى والتوصيلية الحرارية للمواسير [PDF]

Journal of Engineering Research - Egypt, 2018
الملخصان معدل انتقال الحرارة والتوصيلية الحرارية هما من أکثر الخصائصالمباشرة والعملية لتقييم أداء المواد لنقل الحرارة ولا توجد طريقة واحدة يمکناعتمادها لقياس الخواص الحرارية للمواد ولکن تقتصر کل طريقة قياس لتحديدالتوصيلية الحرارية على نطاق محدد من قيم ...
Aly Elzahaby, S. El-Agouz, Mohamed Amro, Mohamed Hegazy   +3 more
doaj   +1 more source

Engineering of Impulse Mechanism for Mechanical Hander Power Tools

IOP Conference Series: Materials Science and Engineering, 2018
The solution to the problem of human security in cities should be considered on the basis of an integrated and multidisciplinary approach, including issues of security and ecology in the application of technical means used to ensure the viability and development of technocracy.
openaire   +1 more source

Mechanisms of vibration damping in heat power engineering structural materials

Journal of Physics: Conference Series, 2020
Abstract This article explores two models of internal friction in porous materials and ultrafine-grain composite materials. The high-temperature background is described by two straight sections based on the dependence of the internal friction value on the reverse temperature or frequency of vibrations.
V G Kul’kov, M M Sultanov, Yu M Chubko, A A Syshchikov, V N Kuryanov   +4 more
openaire   +1 more source