Results 41 to 50 of about 198,328 (259)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

An Apparatus for Measuring Heat Transfer Rate and Thermal Conductivity of Tubes جهاز لقياس معدل الانتقال الحرارى والتوصيلية الحرارية للمواسير [PDF]

Journal of Engineering Research - Egypt, 2018
الملخصان معدل انتقال الحرارة والتوصيلية الحرارية هما من أکثر الخصائصالمباشرة والعملية لتقييم أداء المواد لنقل الحرارة ولا توجد طريقة واحدة يمکناعتمادها لقياس الخواص الحرارية للمواد ولکن تقتصر کل طريقة قياس لتحديدالتوصيلية الحرارية على نطاق محدد من قيم ...
Aly Elzahaby, S. El-Agouz, Mohamed Amro, Mohamed Hegazy   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Particle Swarm Optimization-Support Vector Machine Model for Machinery Fault Diagnoses in High-Voltage Circuit Breakers

Chinese Journal of Mechanical Engineering, 2020
According to statistic data, machinery faults contribute to largest proportion of High-voltage circuit breaker failures, and traditional maintenance methods exist some disadvantages for that issue.
Xiaofeng Li, Shijing Wu, Xiaoyong Li, Hao Yuan, Deng Zhao   +4 more
doaj   +1 more source

Model-Based Control with Active Disturbance Rejection Algorithm for a Diesel Engine

Complexity, 2023
To improve the speed control performance of a diesel engine, the active disturbance rejection controller (ADRC) is designed by adding an arranging transition process to the traditional PID controller, extracting differential signals reasonably, and ...
Shun-Liang Ding, Shuai-Feng He, Bi-Qing Tu, Jin-Jin Liu, Yu-Yuan Wang, En-Zhe Song   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source