Results 171 to 180 of about 2,534,317 (363)
Functions and Training of the Mechanical Engineer
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TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam+9 more
wiley +1 more source
Report of Survey Committee: Progress in Railway Mechanical Engineering, 1967–1968 [PDF]
N. E. Bateson, R. L. Lich, P H Baker
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Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak+14 more
wiley +1 more source
Engineering Design Handbook. Computer Aided Design of Mechanical Systems [PDF]
Jr Haug, J. Edward
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This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini+10 more
wiley +1 more source
Background: The Hip joint is the primary joint which gives stability to the human body. The wear and tear associated with age and other factors, require these joints to be replaced by implants using hip arthroplasty surgeries. Cobalt chromium alloy (CoCr)
Chethan K.N.+4 more
doaj
The roles and applications of extracellular vesicles in cancer
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley +1 more source