Results 91 to 100 of about 2,968,284 (349)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Creep Characterization of Inconel 718 Lattice Metamaterials Manufactured by Laser Powder Bed Fusion

Advanced Engineering Materials, EarlyView., 2023
Herein, the creep characteristics of additively manufactured Inconel 718 metamaterials are investigated. The creep behavior of metamaterials and the effects of microstructural defects are assessed, and the microstructure defects are accurately captured using Kachanov's creep damage model.
Akash Singh Bhuwal, Yong Pang, Ian Maskery, Ian Ashcroft, Wei Sun, Tao Liu   +5 more
wiley   +1 more source

Enhancing the effectiveness of thermal water consumption via heat pumping

Apstract: Applied Studies in Agribusiness and Commerce, 2015
Renewable technologies and the extension of their scope of usage basically has to face the general obstacles like any other novelties newly introduced to the market.
János Nagygál, László Tóth, Bálint Horváth, Zoltán Bártfai, István Szabó   +4 more
doaj   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Conceptual Design and Parametric Optimization of a New Multileveled Horsetail Structure for Bicycle Helmets

Advanced Engineering Materials, EarlyView., 2023
This study aims to explore the feasibility of using a structure inspired by the features of horsetail and human spine as the potential helmet liner, targeting at mitigation of acceleration‐induced injuries. A parametric study is conducted to investigate the effect of individual geometrical variables in the design, indicating its capability to reduce ...
Bing Leng, Dong Ruan, Shanqing Xu, Kwong Ming Tse   +3 more
wiley   +1 more source

Nonlinear forced vibration analysis of composite beam combined with DQFEM and IHB

AIP Advances, 2020
In this paper, a forced vibration model of composite beams under the action of periodic excitation force considering geometric nonlinearity is proposed. For the strain–displacement relationship, Timoshenko beam theory is used, and the element and system ...
Kwangchol Ri, Poknam Han, Inchol Kim, Wonchol Kim, Hyonbok Cha   +4 more
doaj   +1 more source

Subventionen im Maschinenbau [PDF]

, 1999
Das DIW hat im Auftrag der Stiftung IMPULS ein Gutachten erarbeitet, in dem der Frage nachgegangen wurde, in welchem Umfang den Sektoren Maschinenbau und Büromaschinen, ADV Subventionen in Form von Finanzhilfen und Steuervergünstigungen zufließen.
Stille, Frank, Teichmann, Dieter
core  

Hortibot: Feasibility study of a plant nursing robot performing weeding operations – part IV [PDF]

, 2007
Based on the development of a robotic tool carrier (Hortibot) equipped with weeding tools, a feasibility study was carried out to evaluate the viability of this innovative technology. The feasibility was demonstrated through a targeted evaluation adapted
Jensen, Kjeld, Jensen, Lars Aa., Jørgensen, Rasmus N., Maagaard, Jørgen, Nørremark, Michael, Sørensen, Claus G.   +5 more
core   +1 more source

Industry 4.0 and Modification of Study Programs at the Faculty of Mechanical Engineering, UWB Pilsen

, 2020
The paper deals with the topic of industry 4.0 and its use in the preparation and teaching of students of the Faculty of Mechanical Engineering, UWB Pilsen.
J. Basl, M. Edl
semanticscholar   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source