Results 71 to 80 of about 156,715 (315)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Vibration of hydraulic machinery
, 2013 Vibration of Hydraulic Machinery deals with the vibration problem which has significant influence on the safety and reliable operation of hydraulic machinery.
Wu, Yulin +4 more
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Proceedings Of International Conference on Advanced Research in Mechanical Engineering
, 2012 Mechanical Engineering is a traditional field constantly evolving towards new concepts and optimized solutions to existing problems. The mechanical engineering research has become very sophisticated with the introduction of computers and electronics and ...
KUMAR, DR. CH R. VIKRAM, Dept. of Mechanical Engineering
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Utilizing Data from a Sensorless AC Variable Speed Drive for Detecting Mechanical Misalignments [PDF]
, 2013 Conventional condition monitoring techniques such as vibration, acoustic, ultrasonic and thermal techniques require additional equipment such as sensors, data acquisition and data processing systems which are expensive and complicated.
Gu, Fengshou +4 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Modern Engineering : Science and Education
, 2016 This book draws together the most interesting recent results to emerge in mechanical engineering in Russia, providing a fascinating overview of the state of the art in the field in that country which will be of interest to a wide readership.
Evgrafov, Alexander
core +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
ENG450 Engineering Internship: BEC Engineering PTY LTD
, 2010 Once gold ore is mined, using underground or open-cut methods, it is sent to the closest mill where it is crushed into a finely grounded paste. This report discusses two methods employed to start up a large synchronous machine used for milling operations
Colson, Christopher
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