Results 61 to 70 of about 147,466 (260)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A modified squeeze equation for predicting the filling ratio of nanoimprint lithography

Nano Convergence, 2017
A numerical method using the modified squeeze model is proposed in this paper in order to overcome the limitation of the established squeeze equation and obtain filling ratios for nanoimprint lithography (NIL).
JiHyeong Ryu, Ho Lee, Sang-Ho Lee, HyungJun Lim, JaeJong Lee   +4 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

INTEGRATING MECHANICAL AND ELECTRONIC ENGINEERING FOR ENHANCED AGRICULTURAL MACHINERY EFFICIENCY

The rapid advancement of science and technology has ushered in an era of intelligent and automated agricultural production. Concurrently, the domains of machinery and electronic engineering have evolved towards greater sophistication in intelligence and automation, driving the ever-growing demand for control technology.
openaire   +3 more sources

Tuning electro-thermo-mechanical coupling in electroactive nanocomposites for self-oscillating solid-state heat pumps

npj Flexible Electronics
Solid-state cooling based on the electrocaloric effect (ECE) offers low power consumption and zero greenhouse gas emissions. Among various designs of electrocaloric cooling devices, the flexible self-oscillating EC heat pumps, enabled by synergistic ECE ...
Ruhong Luo, Feiyu Zhang, Cenling Huang, Donglin Han, Chengwei Ye, Binzhou Sun, Lu Yu, Shanyu Zheng, Feihong Du, Qiang Li, Yifan Zhao, Zhenhua Ma, Yezhan Lin, Yike Wang, Guangyu Lu, Xi Zhao, Shaochun Tang, Tiannan Yang, Xiaoshi Qian   +18 more
doaj   +1 more source

Development of a Small-Scale Plastic Recycling Technology and a Special Filament Product for 3D Printing

International Journal of Engineering and Management Sciences, 2019
In our days, the fight against pollution has become a real challenge for the state. recycling is one of the solutions that is adopted in several nations to reduce the rate of plastic discarded in nature.
Alaeddine Oussai , Zoltán Bártfai, László Kátai, István Szalkai   +3 more
doaj   +1 more source