Results 41 to 50 of about 368,575 (291)
Review of current knee biomechanical modeling techniques [PDF]
, 2011 In this paper we are going to present an essential modification of an existing analytical model. The model creation normally starts with a simplified, less complex analytical model, where the phenomena can be easily interpreted, checked and controlled ...
Abdel Wahab, Magd +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Influence of the Size of Damage to the Steel Wire Rope on the Magnetic Signature
Sensors, 2022 This article presents diagnostic tests of wire ropes using passive magnetic methods. The study used two types of wire ropes with different constructions and diameters.
Paweł Mazurek +2 more
doaj +1 more source
Adaptive Multiscale Weighted Permutation Entropy for Rolling Bearing Fault Diagnosis [PDF]
, 2020 © 2020 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/.Bearing vibration signals contain non-linear and non-stationary features due to ...
Huo, Zhiqiang +3 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
AIP Advances, 2019 Selective laser melting (SLM) produces complex physical behaviors. After laser melting, the molten pool condenses with an uneven surface, which influences the next powder spreading process and affects the quality of the final product.
Liwei Chen +9 more
doaj +1 more source
The Evolution and Development of Mechanical Engineering through large cultural areas [PDF]
, 2009 Mechanical Engineering is probably the forerunner of many branches of Engineering and has persistently been their companion up to the present. For this reason, the History of Machines embraces a very broad period of the History of Mankind, and can be ...
Bautista Paz, Emilio +9 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Enhancing the effectiveness of thermal water consumption via heat pumping
Apstract: Applied Studies in Agribusiness and Commerce, 2015 Renewable technologies and the extension of their scope of usage basically has to face the general obstacles like any other novelties newly introduced to the market.
János Nagygál +4 more
doaj +1 more source