Results 41 to 50 of about 147,466 (260)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Simulation of surface deformation control during selective laser melting of AlSi10Mg powder using an external magnetic field

AIP Advances, 2019
Selective laser melting (SLM) produces complex physical behaviors. After laser melting, the molten pool condenses with an uneven surface, which influences the next powder spreading process and affects the quality of the final product.
Liwei Chen, Hui Li, Sheng Liu, Shengnan Shen, Tao Zhang, Yicang Huang, Guoqing Zhang, Yunfan Zhang, Bo He, Chongkun Yang   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Optimization and Vibration Response Analysis of Vehicle Suspension Structure With Inerter

Shock and Vibration
The structural composition and component parameters of the suspension will have an impact on the vibration reduction and handling performance of the vehicle.
Haiqing Lu, Fanjie Li, Xiaopeng Li, Haozhe Wang   +3 more
doaj   +1 more source

Enhancing Brain–Computer Interface Performance by Incorporating Brain-to-Brain Coupling

Cyborg and Bionic Systems
Human cooperation relies on key features of social interaction in order to reach desirable outcomes. Similarly, human–robot interaction may benefit from integration with human–human interaction factors. In this paper, we aim to investigate brain-to-brain
Tianyu Jia, Jingyao Sun, Ciarán McGeady, Linhong Ji, Chong Li   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Liquid–film triboelectric nanogenerator with the volume effect for low-frequency blue energy harvesting and shock detection

JPhys Energy
Blue energy is vital for sustainable development, providing a viable alternative to fossil fuels and contributing to climate change mitigation and environmental protection.
Weiyuan Wang, Hao Wang, Ping Wang, Qiuhong Li, Ruoxi Zhao, Yang Jin   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

APPLICATION OF JMODELICA.ORG TO TEACHING THE FUNDAMENTALS OF DYNAMICS OF FOUCAULT PENDULUM-LIKE GUIDED SYSTEMS TO ENGINEERING STUDENTS

Інформаційні технології і засоби навчання, 2017
The present educational research is focused on the solution of didactic problem of an engineering-friendly description and explanation of the dynamics and control of Foucault pendulum-like systems, which have arisen from practical problems of boom crane ...
Alexander V. Perig, Alexander A. Kostikov, Violetta M. Skyrtach, Ruslan R. Lozun, Alexander N. Stadnik   +4 more
doaj