Results 91 to 100 of about 152,111 (265)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

Research Status and Prospect of Finger Rehabilitation Machinery

open access: yesMedical Devices: Evidence and Research
Zhilin Zhang,1,2 Aldrin D Calderon,1 Xingyu Huang,1 Axin Huang1 1School of Mechanical Manufacturing and Energy Engineering, Mapúa University, Manila, 0900, Philippines; 2School of Physics and Telecommunications Engineering, Yulin Normal University,
Zhang Z, Calderon AD, Huang X, Huang A
doaj  

A unified viscoelastic-viscoplastic constitutive framework for optically clear adhesives: Experiments, modeling, and FE validation

open access: yesMicrosystems & Nanoengineering
Optically clear adhesives (OCAs) are extensively employed as bonding layers in display manufacturing. As compliant interlayers in foldable display stacks, they undergo pronounced time and temperature -dependent deformation during repeated bending, which ...
Zhaoxu Zhou   +6 more
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

open access: yesFEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley   +5 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

open access: yesFEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Force Compensation Control for Electro-Hydraulic Servo System with Pump–Valve Compound Drive via QFT–DTOC

open access: yesChinese Journal of Mechanical Engineering
Each joint of a hydraulic-driven legged robot adopts a highly integrated hydraulic drive unit (HDU), which features a high power–weight ratio. However, most HDUs are throttling-valve-controlled cylinder systems, which exhibit high energy losses.
Kaixian Ba   +6 more
doaj   +1 more source

Flat-Knitted Double-Tube Structure Capacitive Pressure Sensors Integrated into Fingertips of Fully Fashioned Glove Intended for Therapeutic Use

open access: yesSensors
A therapeutic glove, which enables medical non-professionals to perform physiotherapeutic gripping and holding movements on patients, would significantly improve the healthcare situation in physiotherapy.
Susanne Fischer   +4 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

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