Results 71 to 80 of about 4,424,668 (298)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
How muscle contraction strengthens tendons
eLife, 2019 The force generated by muscles leads to signaling that helps to shape nearby tendon precursor cells.
Nicole O Glenn, Clarissa A Henry
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Role of the mechanical microenvironment in cancer development and progression
Cancer Biology & Medicine, 2020 Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter the metabolism and behaviors of cancer cells and cause cancer cells to attain ...
Qiuping Liu +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Civil and Environmental Engineering at the U.S. Air Force Academy
, 2007 The goal of the Academy curriculum is to develop well-rounded officers who can meet the unique challenges of the profession of arms. Under the direction of Col Gregory Seely, the department’s 25 faculty members (approximately 75% military and 25 ...
Sloan, Joel, Gwisdalla, David
core +1 more source
Journal of Cachexia, Sarcopenia and MuscleBackground Sarcopenia is a systemic skeletal muscle disease that seriously affects the health of the aged population. Exercise prevents sarcopenia, but the underlying mechanobiological and metabolic mechanisms need to be further investigated.
Yahong Lu +13 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Northeast Regional Meeting of the Kansas Food Safety Task Force, Olathe, Kansas, August 28, 2017.
, 2017 PowerPoint presentation given at the 2015 Northeast Regional Meeting."The Kansas Food Safety Task Force was developed for food and feed safety and defense professionals to achieve prevention, intervention and response including the early detection ...
Kansas Food Safety Task Force.
core +1 more source
The role and mechanism of compressive stress in tumor
Frontiers in OncologyRecent research has revealed the important role of mechanical forces in the initiation and progression of tumors. The interplay between mechanical and biochemical cues affects the function and behavior of tumor cells during the development of solid ...
Min Tan +3 more
doaj +1 more source