Results 41 to 50 of about 49,797 (243)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Detachment efficiency of fruits from coffee plants subjected to mechanical vibrations

Pesquisa Agropecuária Tropical, 2015
The development of efficient machines for the mechanical harvesting of coffee plants requires the use of appropriate vibrational parameters. Thus, in order to detach less unripe fruits and decrease reharvesting, branch breakage and defoliation, it is ...
Andre Luiz de Freitas Coelho, Fábio Lúcio Santos, Francisco de Assis de Carvalho Pinto, Daniel Marçal de Queiroz   +3 more
doaj   +1 more source

Pepper Harvest Mechanism

, 2020
Due to increased food need, plant cultivation issue has started to come up more often. As in all stagesof plant cultivation, the importance of harvesting is also increasing. Due to the consequences of shifting theworkforce to different areas in the developing world, tools and machines manufactured for use in agricultureneed to be mechanized with ...
Tekgüler, Ali, Karaköse, Tuğba
openaire   +1 more source

Comparison between Manual Harvesting and Mechanical Harvesting

Journal of Scientific Research and Reports
This paper presents a thorough analysis of the differences between human and automated harvesting techniques in agriculture, including their categorization, impacts, difficulties, costs, and potential future developments. Manual harvesting, which involves labor-intensive methods, enables meticulous handling and yields top-notch product.
Pargi Sanjay J., Pankaj Gupta, P. R. Balas, V. U. Bambhaniya   +3 more
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mechanical harvesting for green asparagus

California Agriculture, 1969
Results of 1968 Tests Indicate that Substantial Reductions in Yield of Green Asparagus can be Expected with Selective Mechanical Harvesting, as well as with Nonselective Harvesting.
R Kepner, R Cowden, G Weigt
doaj  

Performance evaluation of heat sinks with calcium nitrate tetrahydrate phase change material for electronic cooling

Scientific Reports
The study investigates the influence of heat sink designs and phase change material on the passive cooling of integrated circuits, specifically focusing on input power levels ranging from 4 to 12 W.
Gandhi Mallela, Mohamed Iqbal Shajahan, Ali Cemal Benim, Mohamed Sharaf, Elena Lopez   +4 more
doaj   +1 more source

Date harvest mechanization

California Agriculture, 1966
Research started in 1961 by agricultural engineers of USDA and University of California has led to commercial acceptance of mechanical harvesting methods with resulting labor and cost savings for California date growers. About 65% of the 1965–66 date crop is expected to be harvested with the aid of various mechanical systems that can reduce labor ...
R Perkins, G Brown
openaire   +1 more source