Results 61 to 70 of about 52,540 (262)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Овощи России, 2016 In the system of full diallel crossing 11 x 11, 110 F1 tomato hybrids for mechanical harvesting were obtained. The results of study of the degree of variability and the character of dominance and heterosis effect of F1 hybrids based on economically ...
A. E. Cepordei
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Mechanical harvesting of black corinth raisins
California Agriculture, 1970 The Black Corinth (Zante Currant) is a specialty raisin produced in the central San Joaquin Valley. Its main popularity is with the baking trade where the small, fruity, and tender raisin is ideal.
P Christensen, C Lynn, H Olmo, H Studer
doaj
Mechanical harvesting of oil olives by trunk shaker with a reversed umbrella interceptor
Advances in Horticultural Science, 2012 Trunk shakers are primarily used for the mechanical harvesting of oil olives in intensive orchards. The objective of this trial was to determine the efficiency of mechanical harvesting of olives with a self-propelled trunk shaker with a reversed umbrella
Claudio Di Vaio +3 more
doaj +1 more source
Standardized agronomic practices for mechanical harvesting of the single-harvest garden pea in India. [PDF]
Heliyon, 2023 Dhall RK +5 more
europepmc +1 more source