Results 61 to 70 of about 49,797 (243)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Mechanical harvesting of black corinth raisins
California Agriculture, 1970 The Black Corinth (Zante Currant) is a specialty raisin produced in the central San Joaquin Valley. Its main popularity is with the baking trade where the small, fruity, and tender raisin is ideal.
P Christensen, C Lynn, H Olmo, H Studer
doaj
Acta Scientiarum: Technology, 2016 Detachment of coffee fruit is usually accomplished by means of mechanical impacts and vibrations applied to the plant. Modal properties of the coffee fruit-stem system represent important information for efficient and selective harvesting.
Geice Paula Villibor +4 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Once-over mechanical harvesting for cucumbers
California Agriculture, 1966 Cucumbers (for pickling) can soon be harvested with a commercial machine in a single once-over operation. A commercial prototype machine is available, and the feasibility of the once-over harvesting is enhanced by double-cropping possibilities in ...
M Zahara, W Sims
doaj
Овощи России, 2016 In the system of full diallel crossing 11 x 11, 110 F1 tomato hybrids for mechanical harvesting were obtained. The results of study of the degree of variability and the character of dominance and heterosis effect of F1 hybrids based on economically ...
A. E. Cepordei
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Mechanical Harvesting Feasible for White Asparagus
California Agriculture, 1965 Comparative yields for hand cutting and nonselective mechanical harvesting of white asparagus were determined during the 1964 cannery season, using an experimental harvester. In the tests, the machine-harvested all-white treatment on a peat soil produced
R Kepner
doaj
Mechanically Harvesting Cane Fruits
HortScience, 1980 Abstract The mechanization revolution in the cane fruit industry has been a result of the increasing scarcity and expense of hand labor which has threatened to eliminate cane fruits as a processing crop in the United States.
openaire +1 more source