Results 61 to 70 of about 7,419,589 (253)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Impact of Mechanical Power Normalized to Predicted Body Weight on Outcomes in Pediatric ARDSTake-Home Points

CHEST Critical Care
Background: The topic of mechanical power (MP) in pediatric ARDS (PARDS) is not well explored in the current literature, limiting our understanding of its potentially detrimental effect.
Herng Lee Tan, MSc, Rehena Sultana, MSc(stat), Phuc Huu Phan, MD, Muralidharan Jayashree, MD, Hongxing Dang, MD, Soo Lin Chuah, MBBS, Chin Seng Gan, MBBS, Siew Wah Lee, MD, Karen Ka Yan Leung, MBBS, MSc, Ellis Kam Lun Hon, MBBS, MD, Xuemei Zhu, MD, Pei Chuen Lee, MMed(Paeds), Chian Wern Tai, MD, Jacqueline Soo May Ong, MB BChir, Lijia Fan, MD, Kah Min Pon, MD, Li Huang, MD, Kazunori Aoki, MD, Hiroshi Kurosawa, MD, PhD, Rujipat Samransamruajkit, MD, Jia Yueh Chong, MD, Felix Liauw, MD, Nattachai Anantasit, MD, Wei Xu, MD, Chunfeng Liu, MD, Jan Hau Lee, MBBS, Louise Ngu, MB BCh BAO, Yek Kee Chor, MD, Suparyatha Ida Bagus Gede, MD, Dyah Kanya Wati, MD, Judith Ju Ming Wong, MB BCh BAO   +30 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Impact of wind power on the unit commitment, operating reserves and market design [PDF]

, 2011
Paper presented at the 2011 IEEE Power and Energy Society General Meeting, San Diego, CA, 24-29 July 2011This article highlights and demonstrates the new requirements variable and partly unpredictable wind power will bring to unit commitment and power ...
Milligan, M., Lange, B., Gibescu, M., Michael Milligan, Hannele Holttinen, Lange, Bernard, Kiviluoma, K., Juha Kiviluoma, Meibom, P., Meibom, Peter, O\u27Malley, Mark, Peter Meibom, Madeleine Gibescu, Kiviluoma, Juha; id_orcid, Tuohy, Aidan, Holttinen, H., Tuohy, A., Gibescu, Madeleine, Holttinen, Hannele, O'Malley, M., Milligan, Michael R., Bernhard Lange, Kiviluoma, Juha, Aidan Tuohy, O'Malley, Mark, Mark O'Malley, Kiviluoma, J.   +26 more
core   +1 more source

Other title: Alabama Power Company electric transmission and distribution system

, 1954
Identifies generating plants, substations, types of transmission lines, areas served, and areas served by other ...
Alabama Power Company.
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source