Results 201 to 210 of about 1,339,441 (314)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Study on rheological and mechanical properties optimization and mechanism of Nano-CaCO₃ regenerated aggregate concrete. [PDF]

Sci Rep
Xu J, Lyu GH, Tan M.
europepmc   +1 more source

Experimental and Numerical Indentification of Veneers Mechanical Properties

Computational modelling is an effective tool for development of innovative solutions from cross-ply laminates such as plywood. In order to assure accuracy of such method predetermined material properties should be evaluated.
Ozoliņš, Olģerts, Labans, Edgars, Kalniņš, Kaspars   +2 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Biomimetic and Bioinspired Materials: Design Strategies, Mechanical Properties, and Engineering Applications-A Review. [PDF]

Glob Chall
Karuppusamy M, Palanisamy S, Gurusamy M, Balasubramanian VP, Jayamani M, Sankar SL, Sundararajan K, Sivanantham G, Ali SK, Palaniappan M, Belay M, Abbas M.   +11 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Mechanical Properties of Pediatric Knee Ligaments: A Cadaveric Study. [PDF]

Orthop J Sports Med
Sanchez M, Duru NO, Gupta A, Storaci H, Chan C, Pham N, Rohde M, Khoo B, Alayleh A, Sherman S, Ellis HB, Tompkins M, Wilson P, Green D, Ganley TJ, Shea KG.   +15 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

In-plane hybrid design and mechanical properties of Ti-6Al-4 V TPMS structures. [PDF]

Sci Rep
Fang Y, Yan S, Xie X, Wang C, Ke L, Zhang X, Li Y.   +6 more
europepmc   +1 more source