Results 41 to 50 of about 978,277 (249)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Additive Manufacturing Potentials of High Performance Ferritic (HiperFer) Steels

Applied Sciences, 2022
In the present study, the first tailored steel based on HiperFer (high-performance ferrite) was developed specifically for the additive manufacturing process. This steel demonstrates its full performance potential when produced via additive manufacturing,
Torsten Fischer, Bernd Kuhn, Xiuru Fan, Markus Benjamin Wilms   +3 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The Preliminary Study of Non-Chemical Weed Control for Precision Agriculture by Heated Vegetable Oil [PDF]

E3S Web of Conferences
This study aims to improve the technique for non-chemical weed control by applying heated vegetable oil. Two temperatures of palm oil. at 50 °C and 70 °C. were applied in this experiment to transfer heat energy to the weed.
Netsawang Prud, Kanta Pattaranit, Phuakphasuk Teerapol, Chaitanoo Ninlawan, Junphong Autchara, Srinoun Anuwat, Rajchasom Sureewan, Yawilat Chalorm, Munsin Ronnachart   +8 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Microstructure and Mechanical Properties of Structural Metals and Alloys

Metals, 2018
Mechanical properties of polycrystalline structural metals and alloys are significantly affected by their microstructures including phase content, grain/subgrain sizes, grain boundary distribution, dispersed particles, dislocation density, etc.[...]
Andrey Belyakov
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Detection of former goaf and analysis of deformation characteristics of overburden in Dameidong coal mine

Frontiers in Earth Science, 2023
In order to analyze the deformation of the old goaf in Dameidong Coal Mine and its influence on the surrounding rock and soil layer, it provides guidance for the prevention and control of geological disasters in the region.
Zhan-Xi Wei, Zhan-Xi Wei, Zhan-Xi Wei, Meng Zhao, Fei-Hong Xie, Sheng-Hong Cao, Sheng-Hong Cao, Sheng-Hong Cao, Jian-Hui Dong, Yang-Dan Dong   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source