Results 81 to 90 of about 1,446,577 (354)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Rapid multiple property determination from bulk materials libraries prepared from chemically synthesized powders

Scientific Reports, 2022
A variety of high-performance materials are utilized in electrical, electronic, and mechanical systems. Such systems account for a significant fraction of the world’s electricity consumption.
Li Ping Tan, V. Chaudhary, Z. Tsakadze, R. V. Ramanujan   +3 more
doaj   +1 more source

Characterization of vertically aligned carbon nanotube forests grown on stainless steel surfaces [PDF]

, 2018
Vertically aligned carbon nanotube (CNT) forests are a particularly interesting class of nanomaterials, because they combine multifunctional properties, such as high energy absorption, compressive strength, recoverability and super-hydrophobicity with ...
Daraio, Chiara, Diamantopoulou, Marianna, Johanns, Paul, Parcianello, Giulio, Roumeli, Eleftheria, Serra-Garcia, Marc   +5 more
core   +3 more sources

Development of lightweight fire retardant, low-smoke, high-strength, thermally stable aircraft floor paneling [PDF]

Fire resistance mechanical property tests were conducted on sandwich configurations composed of resin-fiberglass laminates bonded with adhesives to Nomex honeycomb core.
Arnold, D. B., Burnside, J. V., Hajari, J. V.   +2 more
core   +4 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Effect of Thermo-Oxidative, Ultraviolet and Ozone Aging on Mechanical Property Degradation of Carbon Black-Filled Rubber Materials

Buildings
Carbon black (CB)-filled rubber materials are extensively used in civil engineering seismic isolation. However, CB-filled rubber materials often experience mechanical property degradation because of exposure to environmental factors. To better understand
Bo Zhou, Wensong Liu, Youjian Huang, Jun Luo, Boyuan Yin   +4 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Mechanical property evaluation of an Al-2024 alloy subjected to HPT processing

, 2014
An aluminum-copper alloy (Al-2024) was successfully subjected to high-pressure torsion (HPT) up to five turns at room temperature under an applied pressure of 6.0 GPa.
Alhajeri, Saleh N., Das, Goutam, Das, Mousumi, Kori, S.A., Langdon, Terence G., Patil, Deepak C., Venkateswarlu, K.   +6 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Composite propellant technology research: Mechanical property characterization [PDF]

Proof for the existence of a single Poisson's ratio function in isotropic linear viscoelastic materials is presented. An in-depth discussion is given of three dimensional viscoelastic material properties and their relationships to linear isotropic and ...
Bower, Mark V.
core   +1 more source